P30 Limited sampling strategies to predict valganciclovir exposure in kidney transplanted children
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چکیده
منابع مشابه
Sampling strategies and resolution in limited data cone-beam tomography
This paper concerns cone-beam tomography from limited data. Cone-beam tomography is a technique used to visualize the interior of a three-dimensional (3-D) object in a non-invasive way. This technique involves two steps. In the first step, measurements called cone-beam projections are taken. In the second step, digital signal processing techniques are used to process the measurements to form a ...
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Efficacy of anidulafungin is driven by the area under the concentration-time curve (AUC)/MIC ratio. Determination of the anidulafungin AUC along with MIC values can therefore be useful. Since obtaining a full concentration-time curve to determine an AUC is not always feasible or appropriate, limited-sampling strategies may be useful in adequately estimating exposure. The objective of this study...
متن کاملValganciclovir: Dosing Strategies for Effective Cytomegalovirus Prevention
Valganciclovir has widely become the agent of choice for the prevention of cytomegalovirus in recipients of organ transplants. Optimal dosing is needed to achieve efficacy and avoid toxicity. For subjects at high risk of cytomegalovirus, it is strongly suggested that full-dose (based on renal function) valganciclovir be used. While low-dose valganciclovir appears to be efficacious in some repor...
متن کاملLimited-sampling strategies for anti-infective agents: systematic review.
BACKGROUND Area under the concentration-time curve (AUC) is a pharmacokinetic parameter that represents overall exposure to a drug. For selected anti-infective agents, pharmacokinetic-pharmacodynamic parameters, such as AUC/MIC (where MIC is the minimal inhibitory concentration), have been correlated with outcome in a few studies. A limited-sampling strategy may be used to estimate pharmacokine...
متن کاملA growing transplanted kidney
to thrombectomy and finally to thrombolytic therapy with anticoagulation, which is currently the standard treatment of choice [1]. Here, we present a young woman with bilateral RVT. Her case constituted the first clinical report of heterozygous MTHFR mutation with RVT, which was her only risk factor for the disease. MTHFR is a key enzyme for intracellular folate homeostasis and metabolism that ...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2019
ISSN: 0003-9888,1468-2044
DOI: 10.1136/archdischild-2019-esdppp.68